Mechanisms of Warfarin Warfarin is an example of an anticoagulant and according to Boden (1998) anticoagulants are agents which inhibit clotting
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Mechanisms of Warfarin Warfarin is an example of an anticoagulant and according to Boden (1998) anticoagulants are agents which inhibit clotting of the blood. Other examples of anticoagulants include; acenocoumarol, dicoumarol and heparin. Warfarin is probably the most widely used oral anticoagulant in human medicine and is used to control and limit the size of existing blood clots and prevent the formation of new blood clots. Warfarin is also used as a rodenticide and leads to death of rats and mice by internal hemorrhage. In veterinary medicine warfarin is used in the treatment of navicular disease in horses to improve the local blood circulation. Warfarin has two chemical names: * 4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one and * 3-(2-acetyl-1-phenylethyl)-4-hydroxycoumarin and its chemical structure is shown in Figure 1. Blood clotting can be distinguished into intrinsic and extrinsic pathways which lead to the repair of the vascular system following injury. The intrinsic pathway is the pathway that utilizes only the...

