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Discuss the role of the GABAA receptor chloride channel complex in the action of anxiolytic drugs Introduction Anxiolytic drugs are among the most frequently prescribed substances, used regularly by upwards of 10% of the population in most developed countries. This may be a consequence of the difficulties in classifying the difference between a pathological state of anxiety and a normal state of anxiety. The core manifestation of anxiety is experience of excessive anxiety, with other symptoms including: restlessness and agitation; tachycardia; sweating; gastrointestinal disorders; sleep disturbances; and the interference of normal productive activities of the patients every day life. Clinical conditions related to anxiety include phobic anxiety where anxiety is triggered by specific circumstances such as open spaces or spiders, and panic disorder which are attacks of overwhelming fear which occur in association with marked somatic symptoms such as sweating, tachycardia, chest pains, trembling, choking etc. The distinction between these...

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