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Experiment 6 - Methods of Drug Characterization Aims 1. To gain experience of the analytical methods used for drug characterization Objectives 1. To gain experience in melting point determination, thin layer chromatography and UV spectroscopy 2. Application of the methods to identify an unknown substance Introduction The 2 most basic analytical techniques for identification of organic compounds are melting point determination and thin layer chromatography. Identification of compounds relied upon melting point determination before the modern analytical techniques of nuclear magnetic resonance, infrared and UV spectroscopy. Although thin layer chromatography still plays an important role in organic analysis. A solution of the unknown is spotted onto the silica coated plate about 1cm from the bottom and dried; it is then placed vertically into a tank with a suitable solvent inside. The solvent moves up the plate by capillary action and resolves the sample into discrete spots. The plate is removed and dried and the spots are viewed under...

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