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Cholera, tuberculosis, AIDS and malaria are the world's largest killers. Compare the diseases with regard to epidemiology, social problems and the role of drugs

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Have a little read: ... Joshua Randell Biology 27/4/04 Cholera, tuberculosis, AIDS and malaria are the world's largest killers. Compare the diseases with regard to epidemiology, social problems and the role of drugs Epidemiological differences Disease Cholera Malaria AIDS Tuberculosis Pathogen Vibrio Cholerae Plasmodium Falciparum (usually for human malaria) HIV (Human Immunodeficiency Virus) Mycobacterium Tuberculosis (in humans) Methods of transmission Food or water borne. Passed on in contaminated, untreated foodstuffs Insect vector: female anopheles mosquito In semen and vaginal fluids during sexual intercourse, infected blood or blood products, contaminated hypodermic syringes, across placenta, through breast milk Airborne droplets, via unpasteurised milk Global distribution Asia, Africa, Latin America Tropical and sub-Tropical areas Worldwide, particularly in southern Africa and SE Asia Worldwide Incubation Period 1- 5 days A week to a year Initial incubation a few weeks, but up to ten years or more before AIDS symptoms may develop Few weeks or months Site of action of pathogen Wall of small intestine Liver, red blood cells, brain T helper lymphocytes, macrophages, brain cells Primary infection in lungs; secondary infections in lymph nodes, bones and gut Clinical features Severe diarrhoea, like

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