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Describe the application of hyperfractionation OR accelerated fractionation in the clinical setting and discuss the rationale behind the fractionation schedule you have selected - Use a case scenario to illustrate your answer.  

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Chapter VI - Radiobiology 1. 800 words (+-10%), in essay format, double-spaced, typed with a 1 1/2" margin. Quote references if applicable. Describe the application of hyperfractionation OR accelerated fractionation in the clinical setting and discuss the rationale behind the fractionation schedule you have selected. Use a case scenario to illustrate your answer. The case scenario can be that of breast cancer or other cancer sites. I have had little exposure to hyperfractionation in the clinical setting at the NWORCC during my 18 years practicing as a Radiation Therapist. Experience with this unconventional fractionation scheme is through a limited number of patients in the clinical trial setting with advanced unresectable disease of head and neck, non-small cell lung or brain cancers. Through my research, hyperfractionation studies have been preformed all over the world on the following disease sites: cervix, head and neck, lung, esophagus, paranasal sinus & nasopharynx, ovarian, bladder, pancreas, thyroid...

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