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Describe the Mechanism of Action of Diuretics. How does this Help us to Understand the Mechanism of Water and Salt Movements in the Kidney.
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Describe the Mechanism of Action of Diuretics. How does this Help us to Understand the Mechanism of Water and Salt Movements in the Kidney Diuretics cause an effect on the kidneys, to increase the excretion of salt and water. They are used in the treatment of heart failure and oedema (the accumulation of extracellular fluid), but also are used to treat hypertension. General Mechanism of Action Diuretics cause a net loss of water from the body by an action on the kidney, normally associated with a loss of sodium. The effect of causing increased water loss is achieved by decreasing the reabsorption of sodium and chloride from the filtrate. There are two methods of achieving this i. A direct action on the cells of the nephron ii. Indirectly modifying the content of the filtrate As the glomerulus filters such a large volume of water per day, a small decrease in reabsorption can result in a...
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