Anatomical pathology lecture 3 Pleurisy - inflamed pleura Components of acute inflammation

... Anatomical pathology lecture 3 * Pleurisy - inflamed pleura * Components of acute inflammation: 1. vascular an increase in, but relatively static flow of blood (redness, heat) 2. cellular an increase in the number of cells and sometimes haemorrhage (swelling) 3. exudate a protein rich, plasma-like fluid containing fibrinogen which converts to fibrin (swelling, pain, loss of function) * cells of acute inflammation: polymorphs and macrophages * polymorph - alias polymorphonuclear leucocyte, poly, neutrophil or granulocytes. All blood granulocytes are composed of 80% neutrophils 10% eosinophils and 1% basophils. * Macrophages are large scavenger cell, synonymous with tissue histiocyte or> In blood - monocyte> In liver - Kupffer cell> In brain - microglia> Coalesce to form> Epithelioid cells and later giant cells * Post acute injury event sequence 1. momentary arteriolar constriction 2. dilation of small vessels 3. increased permeability of small vessel walls 4. escape of protein rich exudate fluid - oedema 5. haemoconcentration, slowing of blood dynamics 6. margination of leucocytes, along

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