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Establishing linkage between his, ade, leu and lys genes in Saccharomyces cervisiae through random spore analysis
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Establishing linkage between his, ade, leu and lys genes in Saccharomyces cervisiae through random spore analysis Abstract Genes are located within chromosomes, which can either come in haploid or diploid form. When certain genes are on the same chromosome, they are considered linked, and this can then be used to create a linkage map which shows the genes in their relative distances to each other. In haploid Saccharomyces cerevisiae this can be observed by carrying out random spore analysis and a subsequent chi-squared test, and comparing the recombinant frequency and the chi-squared value against a critical chi-squared value to determine if the gene pair is linked or not. The gene pairs his/leu, his/lys and leu/lys were found to be linked, while his/ade, ade/leu and ade/lys were either not linked or too far apart on the same chromosome to behave like it was linked. This tool is useful in identifying the linked genes...
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