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Discuss Recent Developments in our Understanding of the Pharmacology and Biochemistry of Depression Depression is a mental state which along with mania is classed as an affective disorder and can be defined as a pathological moodstate. Depression is usually phasic and is characterised by a return to normality during remission. Classification of depressive orders is very difficult because the disorders are heterogeneous and the symptoms range from mild to severe and can overlap with those of anxiety, schizophrenia and personality disorders. Generally two main types of depression are recognised; bipolar and unipolar. With unipolar depression, the origins of the illness are unknown and there may be periods of normality. Another type of Unipolar depression has been identified as 'reactive depression' and is generally related to environmental circumstances such as bereavement and changes in financial circumstance and is not usually treated with drugs. With bipolar depression or manic-depressive psychosis, there is an oscillation...

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