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The discovery of sulphonamides In 1932, Gehard Domagk began a study of a bright red dye called Protosil, it was found that it caused a remarkable cure of streptococcal infections in mice (in vivo). However it was in active in on bacterial cultures (in vitro) (Fullerton, 1998). Domagk's studies continued on Protosil, and in 1933 the first of many human cures of severe staphylococcal septicaemias was reported. He was awarded the Nobel Prize for medicine and physiology in 1939. Protosil's inactivity in vitro, but excellent activity in vivo attracted much attention. It was not until 1935 the activity of sulphonamides was discovered by Trefouel and co-workers, they reported their conclusions form a structure activity study of sulphonamide azo dyes, that the azo linkage was metabolically broken to release the active ingredient, sulphanilamide (Kucers et al, 1997). Their findings were confirmed by Fuller, in which sulphanilamide was isolated from the blood and...

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