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Mechanism of Insulin Secretion From Pancreatic Beta-cells Of the various factors that can stimulate insulin secretion, glucose is physiologically the most important. This is reflected by the moment-to-moment fluctuations in plasma concentration that accompany fluctuations in plasma glucose concentration. The data shows that glucose metabolism within the cell, rather than a signal from a membranal "glucose receptor" produces the stimulus for insulin release. Supporting this contention is the observation that compounds that inhibit glucose metabolism, for example mannoheptulose, interfere with insulin secretion. It would appear that the products, or intermediates of glycolysis are responsible for insulin secretion. Glucose increases the concentration of glycolytic intermediates within islet cells and so promotes insulin secretion. Mannoheptulose is a sugar that inhibits glycolysis and its presence reduces the amount of insulin secreted. As with many intracellular processes, cAMP participates in the insulin secretory process. cAMP is believed to act as a positive synergistic modulator of a glucose-sensitive secretory...

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