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The DNA Damage Response during DNA Replication
Member rating: No Rating | Words: 621 | Submitted: Thu Jun 21 2007
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Arash Ghaffarpasand 19/01/06 Fundamentals of Biochemistry The Integrative Assignment, Coursework 1 Academic Session 2005/2006 Current Opinion in Cell Biology Volume 17, Issue 6 , December 2005, Pages 568-575 Cell division, growth and death / Cell differentiation The DNA Damage Response during DNA Replication Dana Branzei and Marco Foiani Introduction In the cell life cycle there are some substantial stages including the progressing, stabilising and restarting of the replication fork, where endogenous and exogenous events can confront the genome integrity by stalling the fork. In order to prevent the abnormalities caused by fork stalling, which subsequently makes the chance for cancer to develop, replication forks have a special potential to resume the DNA replication process. In this article the way replication checkpoints participate in processing the mechanisms to stabilise, assist and organise the fork restart is shown, according to recent findings. Endogenous and exogenous events There are some locations in DNA called...
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