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Mabel Akinwumiju Genetics Laboratory 3910 Due: February 25, 2008 TA: Han-Ting Chou Group #2 HDAC8-GeneID: 55869 Bioinformatics Exercise Introduction: Histone deacetylases (HDACs) were originally identified as nuclear enzymes involved in gene transcription regulation. Until recently, it was thought that their activity was restricted within the nucleus, with histones as unique substrates (AVillagra et al). It is known now that Histone deacetylases (HDACs) these are enzymes that regulate the functions of histones as well as non-histones by catalyzing the removal of acetyl groups from lysine residues. This gene belongs to class 1 of the histone. HDACs regulate many biological processes, including the cell division cycle and tumorigenesis. HDAC8, a class I HDAC, is considered to be ubiquitously expressed, as suggested by results of Northern blots performed on tissue RNA extracts, and transfect ion experiments using various cell lines have indicated that this enzyme may display a prominent nuclear localization ( A Bellahcène et al). This aim of...

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