Explain How The Development of Electrophoretic Techniques has played a key role in (a) Our Understanding of Molecular Biology and (b) The Diagnosis of Disease.

... Explain How The Development of Electrophoretic Techniques has played a key role in (a) Our Understanding of Molecular Biology and (b) The Diagnosis of Disease. Barry Hollinshead. Biomedical Sciences Bsc, 2nd yr. CH0575 Biotechniques & Practical Molecular Genetics. Introduction. One of the most widely utilised analytical tools in molecular biology and disease diagnosis is the procedure and methods of electrophoresis. The principle of this procedure is that "electrophoresis is the migration of electrically charged particles or ions in solutions due to an applied electric field"1. The ability to separate substances which are almost identical including different proteins for analysis has increased throughout the past 7 decades. This is contributed to the introduction of zone electrophoresis in paper and more recently in gels like polyacrylamide and agarose. Today the methods used in electrophoresis have increased our advances in biochemistry, molecular biology and studies and diagnosis of disease, for example cancer and it has also become an

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