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Method: Experiment 1 Investigating the inhibitory effect of reserpine on locomotor activity in mice, and its reversal by laevo-DOPA (L-DOPA). A Control Mouse B Reserpine (4mg/kg) treated mouse. Test made 2-hours after administration. C Reserpine (4mg/kg) treated mouse. Test made 3-hours after administration. Note that reserpine induces catalepsy, and the mouse made very few revolutions of the wheel and so I minute recording was not shown D L-DOPA (500mg/kg) treated mouse. Test made 2-hours after administration. E Reserpine (4mg/kg) followed by L-DOPA (500mg/kg). Test made 3-hours after reserpine administration. Experiment 2 Investigating the behavioural effects of amphetamines and chloropromazine in rats. An open field test was conducted with the number of squares the rat enters being used as a measure of their motor activity. A series of tests were conducted under varying conditions, with each test lasting one minute. A Control rat B D-amphetamine (2mg/kg) treated rat. Test made 75 mins after administration C D-amphetamine (2mg/kg) treated rat. Test made 100 mins after administration. 30 second recording with the result doubled D Rat treated...

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