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What are the roles of N- and O-glycans? Use examples to illustrate your answer.
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Glycobiology tutorial II: oligosaccharide function Essay 2: What are the roles of N- and O-glycans? Use examples to illustrate your answer. Although the same glycosylation machinery is available to all proteins which enter the secretory pathway in a given cell, most glycoproteins emerge with characteristic glycosylation patterns and heterogeneous populations of glycans at each glycosylation site. What are the roles of these N- an O-linked glycans? Glycosylation and protein folding: The sugars play a role in protein folding and assembly. The proper folding and controlled assembly of many newly synthesized glycoproteins requires them to engage in a series of coordinated interactions with chaperones and enzymes through the attachment of a common oligosacchardide precursor, GlcNAc2Man9Glc3, to N-linked glycosylation sites. This sugar precursor is rapidly processed to GlcNAc2Man9Glc1 which can bind two lectins: the membrane bound calnexin (Clx) and its soluble homolog calreticulin (Clr). Lectins are oligosaccharide binding proteins. The interaction between Clx and/or...
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