PoMC cell function

... POMC and Human Pigmentation Proopiomelanocortin or POMC and the neuropeptides derived from it, participate in several cardinal processes that control the central nervous system and peripheral tissues. Although, POMC regulates melanocortin or MC receptors in their local activation process, its role in extracellular proteolytic processing has been largely ignored. Several research scientists have been investigating important mechanisms that have significance in controlling the bio-availability of adrenocorticotropin and hormones that stimulate cutaneous melanocyte. This has been done in the context of peptidases like neprilysin - or neutral endopeptidase or NEP, and the ACE or angiotensin - converting enzyme (König et al, 2006, Pp. 751 - 761). The skin constitutes a source, as well as a target organ for the actions of neuropeptides derived from proopiomelanocortin or POMC. These peptides are ACTH, ?-melanocyte stimulating hormone or ?-MCH, and ß-endorphin. The levels of POMC genes and corticotropin releasing hormone peptides or

want to read more? →