Salma Ahmed
English Lit. GCSE Student
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Discuss the role of CaMKII (calcium/calmodulin-dependent kinase II) autophosphorylation in learning and memory
- Words:
- 3994
- Submitted:
- Mon Apr 06 2009
- Mark submitted by Author:
Have a little read: ... Institute of Psychiatry MSc Neuroscience 2007 - 2008 FULL TIME STUDENT ESSAY Module 2: Essay Question No: 10 TITLE Discuss the role of CaMKII (calcium/calmodulin-dependent kinase II) autophosphorylation in learning and memory. WORD COUNT: 3043 MARKER'S COMMENTS: CANDIDATE NUMBER: K22563 PAGE NUMBER: 15 Discuss the role of CaMKII (calcium/calmodulin-dependent kinase II) autophosphorylation in learning and memory. In my essay, I will be discussing the mechanism of CaMKII autophosphorylation and how this process brings about LTP, which contributes to learning and memory. Furthermore I will talk about how the autophosphorylated kinase interacts with the postsynaptic receptors, which underlies the mechanisms of neuronal plasticity. Neural tissues contain many protein kinases and phosphatases and of these protein kinases, calcium-calmodulin dependent protein kinase II (CaMKII) plays an important role in learning and memory. CaMKII is a Ca2+-activated enzyme and makes up 1-2% of the total protein. The kinase is abundantly found in synapses and is one of the main proteins of the postsynaptic density in
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