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Analysis of Aspirin Tablets Aim The objective of this experiment was to determine the percentage of 2-ethanoylhydroxybenzoic acid in Aspirin tablets. Theoretical Background 2-ethanoylhydroxybenzoic acid, also known as acetylsalicylic acid, is an analgesic (pain-killer) drug available under a commercial name of Aspirin. It is an ethanoate ester of salicylic acid, which is obtained from willow bark. Aspirin inhibits the production of prostaglandin synthase, an enzyme essential for production of prostaglandins, that cause swelling, fever, and are responsible for pain transmission to the brain [1]. Figure 1. Structural formula of 2-ethanoylhydroxybenzoic acid. The acetylsalicylic acid makes up only a percentage of Aspirin tablets. The aim of this lab session is to determine the percentage. The method chosen involves an analytical technique of volumetric analysis called back titration. Materials - weighing bottle - semi-analytical, electronic balance - 25cm3-pipette - four 250cm3-conical flasks - magnetic stirrer - 250cm3-standard flask - burette with a stand Table 1. Reagents used. REAGENT FORMULA AMOUNT CONCENTRATION acetylsalicylic acid CH3COOC6H4COOH to be determined n/a sodium hydroxide solution NaOH 25cm3 1.0 moldm-3 water H2O 225cm3 n/a hydrochloric acid solution HCl to be determined 0.10 moldm-3 ...

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