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Preparation of Aspirin Developed by German chemist Felix Hoffmann in 1897 as a treatment for his father's arthritis, the basic ingredients of aspirin had long been known. As long ago as the 500B.C, Hippocrates, the father of modern medicine, used ground willow bark to help pain. Willow bark contains salicin, the basis of a class of drugs called salicylates. One of the best known aromatic acetates is acetylsalicylic acid, or aspirin, which is prepared by the esterification of the phenolic hydroxyl group of salicylic acid. The key compound in the synthesis of aspirin, salicylic acid, is prepared from phenol by a process discovered over 100 years ago by the German chemist Hermann Kolbe. In the Kolbe synthesis (also known as the Kolbe-Schmitt reaction) sodium phenoxide is heated with CO2 under pressure and the reaction mixture is subsequently acidified to yield salicylic acid. 2-hydroxybenzoic acid (salicylic acid) can be converted by straightforward...

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