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Biology Report
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| Submitted: Fri Mar 04 2005
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Biology Report Hypothesis Orlistat can inhibit the action of lipase; therefore lipase cannot breakdown fat molecules. Aim To demonstrate that Orlistat reduces the absorption of fat by inhibiting lipase. Principle Oristat is a lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats. In a normal human body, gastric and pancreatic lipase are responsible for breaking down fat molecules and producing absorbable fatty acids and glycerol. However, in the lumen of the stomach and small intestine, Orlistat works by forming a covalent bond with the active site of lipase. The inhibited enzymes are unable to hydrolyze fat, reducing the absorption of fat. In this experiment, the experimental setup test whether Orlistat can inhibit the lipase added, so that no fat is broken down. To make the experiment fair, there should be a control setup. There are a few variables needed to be set. They are as follows: Independent variable- presence of...
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