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OBJECTIVES The objectives of this investigation are: 1) Research available literature on aspirin with reference to synthesis, history, and medical use. 2) Prepare a pure sample of aspirin starting with oil of wintergreen as the initial compound. 3) Verify the identity and measure purity of the manufactured aspirin using a range of techniques. 4) Devise additional investigations into manufacture, properties or usage of Aspirin. Background Information Aspirin or acetylsalicylic acid is made from salicylic acid, found in the bark of the willow tree, which was used by the ancient Greeks and Native Americans, among others, to counter fever and pain. Salicylic acid is bitter and irritates the stomach. The German chemist Felix Hoffman synthesized the acetyl derivative of salicylic acid in 1893 in response to the urging of his father, who took salicylic acid for rheumatism. Aspirin is currently the first-choice drug for fever, mild to moderate pain, and inflammation due to arthritis or injury. It is...

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