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There are several mentions of heart transplantation in ancient mythology and biblical reference, but it was the pioneering work of Alexis Carrel at the beginning of the 20th century that made organ transplants a real possibility.
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References: Braunwald, Heart disease textbook 5th ed. There are several mentions of heart transplantation in ancient mythology and biblical reference, but it was the pioneering work of Alexis Carrel at the beginning of the 20th century that made organ transplants a real possibility. The next reported heart transplantations were those of Mann at the Mayo Clinic in 1933. These dog heart transplants were able to function until the onset of rejection at eight days. After these experiments, there was a 20-year period without progress until the late 1940s. S.V.P. Demikhov, a Russian surgeon, then initiated a series of ingenious experiments on the technical feasibility of both intra thoracic heart transplants as well as heart lung transplantation, although his work was not reported in the West until 1962. With the advent of techniques for successful heart surgery in the 1950s, major attention was finally given to heart transplantation. Various experiments using either...
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