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Discuss the interplay of infectious agents and the immune system in pathogenesis of arthritis. The pathogenic mechanisms of the various manifestation of arthritis commonly involve infectious triggers that mediate the disease-causing damage. These generalised mechanisms of pathogenicity include many interactions of the host's immune system and any infectious agent. There is a subtle balance between an effective immune response to eliminate the infecting organism from the host and the over-activation of this response that causes the majority of infection-related joint destruction. In infectious arthritis, infection of joints occurs in one of two ways: * by direct involvement, as in open wounds and extension of infection from adjacent structure * the haematogenous route Involvement is usually monoarticular in nature & the larger joints of the lower limb are those more commonly affected. This form of arthritis is potentially serious because it can cause rapid destruction of the joint and produce permanent defects. Infection of joints...

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