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The citric acid cycle has been described as "the hub of the metabolic wheel". Discuss the roles of the citric acid cycle in the oxidation of various fuel molecules and the provision of carbon skeletons for biosynthesis
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The citric acid cycle has been described as "the hub of the metabolic wheel". Discuss the roles of the citric acid cycle in the oxidation of various fuel molecules and the provision of carbon skeletons for biosynthesis The citric acid cycle is one of three stages of cellular respiration. The others are glycolysis and electron transport or oxidative phosphorylation. Glycolysis breaks one glucose molecule, producing six ATP (adenosine triphosphate) molecules, a fundamental energy provider in cells. Pyruvate is used to make acetyl-CoA, the starting product for the citric acid cycle. The reaction involves oxidation and decarboxylation of a 3 carbon pyruvic acid to form 2 carbon acetyl Co-A. It occurs in the cell cytoplasm and requires the presence of co-enzyme-A and NAD. It is catalyzed by complex enzymes. In this process, carbon dioxide is released and the reduced co-enzyme NADH2 is formed. 2 Pyruvic acid + 2Co-A + 2NAD --> 2 Acetyl Co-A...
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