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Urea Cycle Nitrogen containing compounds cannot be stored in the body and therefore any excess of these
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Urea Cycle Nitrogen containing compounds cannot be stored in the body and therefore any excess of these must be excreted to prevent poisoning. Most aquatic species, such as bony fishes, excrete amino nitrogen as ammonia and are thus called amonotelic animals; most terrestrials animals excrete amino nitrogen in the form of urea and are thus ureotelic; and birds and reptiles excrete amino nitrogen as uric acid and are called uricotelic. Plants recycle virtually all amino groups, and nitrogen excretion occurs only under very unusual circumstances hence there is no general pathway for nitrogen excretion. In ureotelic organisms, the ammonia in the mitochondria of hepatocytes is converted to urea via the urea cycle. The urea cycle was discovered by Hans Krebs and Kurt Henseleit who found it almost exclusively occurs in the liver. In their experiments they revealed that urea formation from ammonia was greatly accelerated by adding any one of three amino...
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