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Sensitised Guinea Pig Ileum. (Hypersensitivity type1) Aims. An experiment was conducted to investigate hypersensitivity type 1 (allergic reactions) and the effects that different doses (0.2 10-4 m and 0.4 10-4 M) of histamine had on the guinea pig ileum (tissue). The different effects that mepyramine and carbachol had on the guinea pig ileum were also investigated. A piece of tissue from a guinea pig's ileum, which had been 1, non-sensitised and 2, sensitised to egg albumin were exposed to mepyramine, carbachol and different doses of histamine. The experiment was to illustrate any differences that occurred between the sensitised guinea pig ileum and the non-sensitised guinea pig ileum. The control experiment was the non-sensitised guinea pig's ileum (tissue). Introduction. The immune/ inflammatory system is designed to fight against infections foreign substances/molecules that invade the body, these foreign substances can be specifically recognised by the white cells in the blood stream. T-Lymphocytes pass through...

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