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Parkinson's disease and action of drugs on movement Introduction: Parkinson's disease is a neurological disorder that seriously impairs motor function, with people afflicted with this condition exhibiting akinesia, muscle rigidity and having a tremor at rest. It is accepted that the loss of motor function is brought upon by the progressive degeneration of nigrostriatal dopamine neurons, which leads to a corresponding loss of dopamine in the caudate/putamen part of the basal ganglia, which is accepted as the main receiving area in motor circuits. Information coming to it from the cortex and thalamus is processed and channeled to the pallidum and to the substantia nigra reticular. There are two main pathways from the striatum to the pallidum, the direct pathway and the indirect pathway, and so loss of dopamine, which usually serves to activate the direct pathway and inhibit the indirect pathway, results in a loss of the tonic inhibitory influence on GABA...

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