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How do Cytotoxic T cells recognise and kill virally infected cells?
Member rating: No Rating | Words: | Submitted: Mon Dec 22 2003
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How do Cytotoxic T cells recognise and kill virally infected cells? * Cytotoxic t- cells are developed from precursors in the thymus. * They develop from naïve CD8 t cells (called thus due to presence of CD8 molecule which is important in antigen binding). * They recognise antigens via t-cell receptors (TCRs) on the cell surface - a single cell may have up to 300000 identical TCR's - these are similar to immunogloulin molecules - each TCR has an alpha and a beta region T cells have different amino acid sequences in the variable region of the TCR receptors, this is what causes specificity. This specificity is crucial as it allows cytotoxic t cells to recognise and bind to the many different foreign antigens which might invade our bodies. Naïve cytotoxic t cells -T cells which have not yet met their specific antigens are called naïve t cells. -naïve CD8 t cells will later develop into cytotoxic t...
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