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Discuss how chromosomal DNA is organized in the nuclei of eukaryotic cells. What is the relevance of this for regulation of gene expression? How does DNA packaging/organization change during the cell cycle?
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enetic information to the next generation. On this information is encoded in DNA which is encased in the nucleus of every cell. If just these fragile strands of DNA were to replicate and be moved about during cellular division they would be tangled and broken. This would not be a good situation for the organism as it would be unable to pass on its genetic information. Also there is a huge amount of DNA in a nucleus and if it were stretched out would cross the nucleus thousands of times. So there is a problem that the cells must face; how to fit all this DNA into a nucleus and how to safely manipulate it during cellular division. Chromosomal DNA Organisation The solution is to package the DNA into a compact structure with the aid of specialised proteins. The amount of DNA binding proteins is roughly similar to the amount of DNA...
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