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What is the Risk of New-variant Creutzfeldt-Jakob Disease on Blood Transfusion Part 1: Variant Creutzfeldt-Jakob Disease (vCJD) is the human form of Bovine Spongiform Encephalopathy (BSE). It is a transmissible spongiform encephalopathy (TSE), which are a group of fatal neurodegenerative disorders , also including scrapie in sheep, BSE in cattle and CJD in humans, (Baker et al, 1998). The New-variant Creutzfeldt Jakob disease (nvCJD) is a new form of TSE in humans, first identified in 1996 in the UK, (Will et al, 1996). nvCJD differs from the classical form of CJD and develops clinical symptoms that are markedly different than those from other forms of CJD. Patients with nvCJD present at a relatively young age and differences in clinical features include behavioural changes, dysaesthesia and ataxia and development of progressive dementia leading to death after around 7 1/2 - 22 1/2 months, after the incubation period (Turner, 1999), which is still unknown,...

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